Endocrine Abstracts

Some studies reports the high prevalence of unsuspected hypercortisolism in high-risk populations.Aim: To evaluate the prevalence of undiagnosed hypercortisolism in patients with diabetes mellitus (DM), adrenal incidentaloma and obesity.Material and methods: We prospectively evaluated 30 DM patients (8 male, 22 female, 53.5 years old (18; 73), HbA1c-7.1% (5.6; 13.8)), 22 patients with adrenal incidentaloma (6 male, 16 female, 53.5 ...

Objective: To evaluate the frequency of symptoms of Cushing’s disease (CD) at baseline and it dependence on different quantities.Material and methods: Clinical and laboratory data of 44 patients with CD (40 females and four males, 37.9±10.5 years old), duration of the disease 35.5 (22; 75) months.Results: Complaints: i) >80% – fatigability, weight gain, apathy, and headache, ii) 40–50% – loss of libido,...

Background: Excessive level of cortisol in patients with Cushing’s disease (CD) can cause an immunosuppression. Therefore after resolution of hypercorticism the underline autoimmune disorders can appears.Aim: We are presenting three cases of autoimmune disorders diagnosed in patients successfully treated for CD.Results: Case 1: Woman, 37-year-old with confirmed panhypopituitarism after transsphenoidal adenomectomy (TSA) for CD...

Background: It has been hypothesized that patients with type 2 diabetes mellitus (DP) are very suspicious to have hypercortisolism, especially those which a high HbA1c level. The prevalence of hypercortisolism also could be high in obese patients (OP).Methods: To 111 DP (male:female, 1:3; 58 (50; 64) years old; HbA1c, 9.5±2.2%), and 39 OP (male:female 2:1, 22 (20; 28) years old) 1 mg dexamethasone suppression test (DST-1) have been done. If post-DST...

Introduction: To analyze clinical, laboratory and anamnestic data of the patients with Cushing’s disease (CD) we conducted a CD database.Methods: One hundred and eighty patients with CD were investigated in MRRCI from 1975 year. To all of them in 2011 the invitation letter was sent. In only 22 patients we could confirm diagnosis of CD according to their medical documentation. Three patients died to 2011. From 2009 to 2012 in 16 patients CD were newl...

Background: BIPSS is the most reliable procedure for differentiation Cushing’s disease (CD) from ectopic ACTH secretion (EAS).Aim: To determine the comparability of 8-mg dexamethasone supression test (BDST) and BIPSS for differential diagnosis ACTH-dependent hypercortisolism.Materials and methods: We present 6 patients with confirmed ACTH-dependent hypercortisolism. All of them BDST (8 mg dexamethasone at 2300 h) and BIPSS (wi...